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    Questions? Ask Henci!

    Find out what other moms-to-be are asking. Join in the discussion with Henci Goer, whose expertise is determining what the research tells us best promotes safe, healthy birth. If you would like to contact Henci outside of the Ask Henci forum, send an email to

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    Archived User

    What are your thoughts on giving RhoGam at 28 weeks pregnancy?

    Henci Goer

    It's not something I'm up on, but here is a link to a website with a good, general explanation of the issues. What it lacks, however, is any discussion of whether there are any negative aspects to RhoGam treatment.

    -- Henci

    Katheryn Markham

    I have a student asking about this too.  Do you have any other sources of guidance on the pros/cons of the prenatal rhogam shot?

    Henci Goer

    My go-to website for reliable health information is MedLine Plus, the consumer health website run by the U.S. government. When I searched it using the terms "Rh incompatibility" it came up with this. I didn't check out the links, but I would predict that they will have the same drawback as in my original response, namely that there is no info on adverse effects. The standard for making an informed decision is to have both. Still, I have never heard or read anywhere that Rhogam has had adverse effects, and I think it would have stuck in my mind if I had.  

    Rebecca Meinke
    [Positively Beautiful Birth Service]

    As I understand it, Rhogam works by diminishing the mother's immune response and therefore preventing her body from producing antibodies to the foreign blood antigen. Considering this, there must be a consequence of routinely using the drug. Maybe the negative effects are minute or do not have clinical significance, but I am still weary of it's use during a normal pregnancy when the chances of the maternal and fetal blood mixing are extremely small.

    Henci Goer

    Well, as I wrote, it isn't a topic I've ever researched. If you want to give it a try, here is the gateway to PubMed, the U.S. National Library of Medicine. If you find anything to the point, that would be great.

    ~ Henci

    All Times America/New_York

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